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HomePrevnar 20®Prevnar 20®Serotypes matterAdministrationBurden of diseaseBurden
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Prescribing InformationIndicationPatient SiteOrder Prevnar 20®
Broad protection against 20 medically important serotypes,including 9 serotypes not included in PCV211-10*† Key serotypes in Prevnar 201,3-10
Pneumococcal Pneumonia
Bacteremia
Meningitis
 Disease severity
Serotypes 1, 3, 19F, and 23F were among the most virulent serotypes causing pneumococcal pneumonia based on 1 epidemiological study of hospitalized patients prior to the availability of Prevnar 201,11‡
  Antibiotic resistance
Prevnar 20 includes some of the most concerning antibiotic-resistant serotypes prior to the launch of PCVs.1,12

 
  • The impact Prevnar 20 will have on antibiotic-resistant pneumococcal serotypes is yet to be determined.
 High prevalence
Serotype 4 IPD has been emerging as a prevalent serotype, and serotype 4 is not included in PCV21.2
 
  • In certain adult populations in the Western US with data (AK, CO, NM, Navajo Nation, and OR), serotype 4 has caused high percentages (ie, ≥30%) of IPD.§ Typically, adults who develop serotype 4 IPD are aged <65 years with specific underlying conditions or risk factors such as alcoholism, chronic lung disease, cigarette smoking, homelessness, and injection drug use.2
 
The CDC advised that in such populations, pneumococcal vaccines like PCV20 are expected to provide broader serotype coverage against locally circulating strains compared to PCV21 alone.2,13

There are no efficacy studies comparing PCV21 and PCV20.
 View patient types eligible for Prevnar 20 Patient ProfilesLoadingReferences:CDC=Centers for Disease Control and Prevention; IPD=invasive pneumococcal disease; PCV=pneumococcal conjugate vaccine; PCV20=20-valent pneumococcal conjugate vaccine; PCV21=21-valent pneumococcal conjugate vaccine; UAD=urinary antigen detection.*Prevnar 20 will only help protect against the 20 Streptococcus pneumoniae serotypes in the vaccine.1 †PCV21 covers serotypes 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15B, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F, and 35B.14‡Based on a population-based study examining 5402 adults hospitalized for community-acquired pneumonia over a 2-year period from 2014 to 2016 in Louisville, Kentucky. One of the study limitations includes reliance on the UAD-24 platform for serotyping that can detect 24 of ~100 Streptococcus pneumoniae serotypes (1, 2, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F), potentially underestimating S. pneumoniae cases and serotype distribution and the prepandemic time frame which may not reflect current epidemiology.11,15§The 30% threshold was guided by economic models that showed that once the percentage of cases of pneumococcal disease caused by serotype 4 exceeds 30%, PCV21 use might result in higher cost and, in some cases, worse health outcomes compared with PCV20 use.2References:Prevnar 20® (Pneumococcal 20-valent Conjugate Vaccine) Prescribing Information. Wyeth Pharmaceuticals LLC, 2023. Kobayashi M, Leidner AJ, Gierke R, et al. Expanded recommendations for use of pneumococcal conjugate vaccines among adults aged ≥50 years: recommendations of the Advisory Committee on Immunization Practices — United States, 2024. MMWR Morb Mortal Wkly Rep. 2025;74(1):1-8. Hausdorff WP, Hanage WP. Interim results of an ecological experiment—conjugate vaccination against the pneumococcus and serotype replacement. Hum Vaccin Immunother. 2016;12(2):358-374. Oligbu G, Collins S, Sheppard CL, et al. Childhood deaths attributable to invasive pneumococcal disease in England and Wales, 2006-2014. Clin Infect Dis. 2017;65(2):308-314. van Hoek AJ, Andrews N, Waight PA, George R, Miller E. Effect of serotype on focus and mortality of invasive pneumococcal disease: coverage of different vaccines and insight into non-vaccine serotypes. PLoS One. 2012;7(7):e39150.Stanek RJ, Norton NB, Mufson MA. A 32-year study of the effect of pneumococcal vaccines on invasive Streptococcus pneumoniae disease. Am J Med Sci. 2016;352(6):563-573. Harboe ZB, Thomsen RW, Riis A, et al. Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study. PLoS Med. 2009;6(5):e1000081. Tomczyk S, Lynfield R, Schaffner W, et al. Prevention of antibiotic-nonsusceptible invasive pneumococcal disease with the 13-valent pneumococcal conjugate vaccine. Clin Infect Dis. 2016;62(9):1119-1125. Mendes RE, Hollingsworth RC, Costello A, et al. Noninvasive Streptococcus pneumoniae serotypes recovered from hospitalized adult patients in the United States in 2009 to 2012. Antimicrob Agents Chemother. 2015;59(9):5595-5601. Suaya JA, Mendes RE, Sings HL, et al. Streptococcus pneumoniae serotype distribution and antimicrobial nonsusceptibility trends among adults with pneumonia in the United States, 2009–2017. J Infect. 2020;81(4):557-566. Ramirez J, Furmanek S, Chandler TR, et al; The University of Louisville Pneumonia Study Group. Epidemiology of pneumococcal pneumonia in Louisville, Kentucky, and its estimated burden of disease in the United States. Microorganisms. 2023;11(11):2813. Centers for Disease Control and Prevention. Antibiotic-resistant Streptococcus pneumoniae. December 17, 2024. Accessed April 30, 2025. https://www.cdc.gov/pneumococcal/php/drug-resistance/index.html Centers for Disease Control and Prevention. Summary of risk-based pneumococcal vaccination recommendations. May 24, 2025. Accessed June 27, 2025. https://www.cdc.gov/pneumococcal/hcp/vaccine-recommendations/risk-indications.html CAPVAXIVE™ (Pneumococcal 21-valent Conjugate Vaccine) Prescribing Information. Merck Sharp & Dohme LLC, 2024. Ramirez JA, Hubler RA, Ali M, et al. Streptococcus pneumoniae serotype distribution among US adults hospitalized with community-acquired pneumonia, 2019-2020. Open Forum Infect Dis. 2024;12(1):ofae727. Prevnar 20®      Order Prevnar 20 for your office by registering for Prime Get started Loading
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INDICATION AND SELECT SAFETY INFORMATION
  • Prevnar 20® is a vaccine approved for:​​​​​
    • active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
    • active immunization for the prevention of pneumonia caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 18 years of age and older
  • The indication for the prevention of pneumonia caused by S. pneumoniae serotypes 8, 10A, 11A, 12F, 15B, 22F, and 33F in individuals 18 years of age and older is approved under accelerated approval based on immune responses as measured by opsonophagocytic activity (OPA) assay. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial
SELECT SAFETY INFORMATION
  • Do not administer Prevnar 20® to individuals with severe allergic reaction (eg, anaphylaxis) to any component of Prevnar 20® or to diphtheria toxoid
  • Safety and immunogenicity data on Prevnar 20® are not available for individuals in immunocompromised groups and vaccination should be considered on an individual basis. Based on experience with pneumococcal vaccines, individuals with altered immunocompetence may have reduced immune responses to Prevnar 20®
IMPORTANT SAFETY INFORMATION
  • Do not administer Prevnar 20® to individuals with severe allergic reaction (eg, anaphylaxis) to any component of Prevnar 20® or to diphtheria toxoid
  • Safety and immunogenicity data on Prevnar 20® are not available for individuals in immunocompromised groups and vaccination should be considered on an individual basis. Based on experience with pneumococcal vaccines, individuals with altered immunocompetence may have reduced immune responses to Prevnar 20®
  • In individuals 18 years of age and older, the most commonly reported solicited adverse reactions (>10%) were pain at the injection site, muscle pain, fatigue, headache, and arthralgia. Additionally, injection site swelling was also reported (>10%) in individuals 18 through 59 years of age
Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please click for Prevnar 20® Full Prescribing Information.INDICATION
  • Prevnar 20® is a vaccine approved for:
    • active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 6 weeks of age and older
    • active immunization for the prevention of pneumonia caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F in individuals 18 years of age and older
  • The indication for the prevention of pneumonia caused by S. pneumoniae serotypes 8, 10A, 11A, 12F, 15B, 22F, and 33F in individuals 18 years of age and older is approved under accelerated approval based on immune responses as measured by opsonophagocytic activity (OPA) assay. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial